Invokana for DKD – Renal Consequences

Kidney image
 

Invokana for DKD – Renal Consequences

Burden of DKD

The renal consequences of insufficiently controlled type 2 diabetes mellitus (T2DM)

Kidney image

~40% of T2DM patients are affected by diabetic kidney disease (DKD), making it one of the most common complications of T2DM.1

Euro symbol

80% of the cost of managing T2DM is spent managing complications such as DKD and cardiovascular disease (CVD).2

A patient taking saline

£26,835 the annual mean NHS England cost of managing one patient on dialysis.3

The link between declining kidney function and mortality

~30% of patients with T2DM have moderately or severely increased albuminuria.4

A bar graph showing link between declining kidney function and mortality

"Kidney disease predominantly accounts for the increased mortality observed
in type 2 diabetes5"
Abbreviations

CI: Confidence Interval; CVD: Cardiovascular Disease; DKD: Diabetic Kidney Disease; GFR: Glomerular Filtration Rate; NHS: National Health Service; T2DM: Type 2 Diabetes Mellitus.

References
  • 1. Diabetic nephropathy – kidney disease. Available at: https://www.diabetes.co.uk/diabetes-complications/kidney-disease.html [Accessed May 2021].
  • 2. Hex N, et al. Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet Med. 2012;29(7):855-862. doi:10.1111/j.1464-5491.2012.03698.
  • 3. Kerr M. Chronic Kidney Disease in England: The Human and Financial Cost. Available at: https://www.england.nhs.uk/improvement-hub/wp-content/uploads/sites/44/2017/11/Chronic-Kidney-Disease-in-England-The-Human-and-Financial-Cost.pdf [Accessed May 2021].
  • 4. Bramlage P, Lanzinger S, van Mark G, et al. Patient and disease characteristics of type-2 diabetes patients with or without chronic kidney disease: an analysis of the German DPV and DIVE databases. Cardiovasc Diabetol. 2019;18(1):33. Published 2019 Mar 16. doi:10.1186/s12933-019-0837.
  • 5. Afkarian M, Sachs MC, Kestenbaum B, et al. Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013;24(2):302-308. doi:10.1681/ASN.2012070718.
Reporting adverse events

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard.

Adverse events should also be reported to Napp Pharmaceuticals Limited on 01223 424444 or drugsafetyuk@napp.co.uk.